shuttle842 wrote:in Audio/MIDI settings controller appears normally .. but it just dont work
Do you see it going online/offline or always online ?
It should be always online.
when i bought it i didn't think there will be issues on OSX

You certainly buy it as the Windows product as it is not mentionned that it work with Mac.
Which version of OSX is the most compatible one?
i would say any, as far as you don't have frequent disconnect/reconnect (I have...).
am I the only one who cannot get headphones to work?

Yes, because when mine is online, everything work.
Is there firmware upgrade maybe?
There was, but again, this is not designed for a Mac, so even the upgrade don't add anything for a Mac.
shuttle842 wrote:Headphones on U46MK2 should work OK on Mac?
Yes.
I can preview music, but i cannot set cue to disable Mix output so i always hear mix out in my headphones
It's because the headphones connectors on the U46 is a monitor mix, all the sound of the soundcard is mixed there.
If you want to listen only to your monitor output, you need to connect the headphones with an adapter to the outputs you have assigned to the monitor.
probably i had to connect my headphones to Output 2 not headphones jack on my U46MK2
That's it.
How do you connect your Vfx to your Mac ? Direct usb or an usb hub ?