Sound Card issues

My mixvibes crosspack was working fine and then I turned it off and came back a few hours later and now it will not load Mixvibes ASIO U46MK2 driver. I just keep getting a message saying "Your U46MK2 is already used by some other processes. Quit them all and retry." So I've restarted PC and reconnected sound card. I've uninstalled and reinstalled audio drivers but still will not load drivers so I can't mix. Any help would be greatly appreciated.
Also I get really bad sound from the output of channel 1 on my soundcard. I have to open the mixvibes panel board and take the output on channel 1 down to about -24.0de to hear decent sound but when I do this channel 1's volume is really low and I can't hear it all that well and I end up having to turn channel 1 fader volume all the way up to hear anything. Any ideas?
Also I get really bad sound from the output of channel 1 on my soundcard. I have to open the mixvibes panel board and take the output on channel 1 down to about -24.0de to hear decent sound but when I do this channel 1's volume is really low and I can't hear it all that well and I end up having to turn channel 1 fader volume all the way up to hear anything. Any ideas?