Your welcome man...hope it all goes smooth from here..
Well the bypass button is just for when using real vinyl.
Onto your problem; If the noise that your are hearing sounds like a high pitched drone, it comes from the control records...
You have to put the OUTPUTS to zero, not mute the vinyls(turntables).
The computer needs the DATA signals to control the software, not the audible data as you don't want to hear that crap!!!
Cant remember clearly on the U46mk2 how to do it, but i think it might be on the front panel. Direct and mix knob? There might be a related post in regards to the U46mk2 controls.
happy spinning

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(User Control Panel>Profile>Serial#)ASUS i7 ROG G51,4G ram
Samsung 256gSSD +320g Dual HD's
Edirol FA66 FWire @ 48.kHz + U46 MK2
U-Mix Control Pro 2
Korg PadKontrol
Numark DXM06
Technics 1200 mkII X 2
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